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  • Chem Sci Trans., 2015, 4(4),  pp 1156-1162  

    DOI:10.7598/cst2015.1134

    Research Article

    Synthesis and DNA Binding of cis-Dichlorobis-benzimdazolebis-(dimethylsulfoxide)ruthenium(II)- hydrate Complexes

  • JITENDRA DEKA1, KIBRIYA SIDDIQUE2, PANKAJ HAZARIKA1, OKHIL KUMAR MEDHI1, SANJIB KARMAKAR2 and CHITRANI MEDHI1*
  • 1Department of Chemistry, Gauhati University, 2Department of Instrumentation & USIC- Gauhati University, Guwahati-781014, Assam, India
  • Abstract

    The ruthenium complex with substituted imidazole ligand of formula [Ru(BIm)2(DMSO) 2Cl2].H2O (BIm=Benzimidazole) was prepared. The compound has been further characterized from spectroscopic data and elemental(C, H and N) analysis. The molecular structure of this compound was determined by single crystal X-ray diffraction study. Binding of this complex with plasmid-DNA was studied by UV-Visible and Emission spectral studies. Further electrochemical studies were performed to understand the DNA binding ability of this complex. The evidences of DNA binding were found from the change of the Intensity of fluorescence band and UV-band. Binding constant (Kb) calculated from UV-Spectroscopic titration is found to be 9.09 x 105M-1.

    Keywords

    Benzimidazole, DMSO, X-ray diffraction, Electrophoresis, Plasmid-DNA

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