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  • Chem Sci Trans., 2018, 7(2),  pp 240-246  

    DOI:10.7598/cst2018.1473

    Research Article

    Synthesis of Highly Functionalized Piperidines by One-Pot Multicomponent Reaction Using Boron Trifluoride Etherate

  • A. APPALA NAIDU and G. VEERA RAGHAVA SHARMA*
  • Department of Chemistry, GITAM Institute of Technology, GITAM University Rushikonda, Visakhapatnam-530045, AP, India
  • Abstract

    One-pot, atom and step economic synthesis of highly functionalized piperidines has been developed based on a low-cost and environmentally benign boron trifluoride etherate catalyst. The procedure simply involves the condensation of aromatic aldehydes, β-ketoesters and aromatic amines in ethanol at room temperature.

    Keywords

    Etherate, Functionalized piperidines, Aryl aldehyde, One-pot synthesis and characterization

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