Abstract

A facile synthesis of 6,7-di-[substituted]-phenyl-3-pyridin-4-yl-5H-[1,2,4]-triazolo-[3,4-b]-[1,3,4]-thiadiazines have been carried out by reacting 4-amino-3-mercapto-5-pyridin-4-yl-4H-[1,2,4]-triazole with substituted benzoins in presence of potassium hydroxide. The required 4-amino-3-mercapto-5-pyridin-4-yl-4H-[1,2,4]-triazole was synthesized by reacting isoniazide with carbon-disulphide and potassium hydroxide followed by the addition of hydrazine hydrate. The acetylation of triazolo-thiadiazines afforded monoacetyl derivatives. The constitution of synthesized compounds have been delineated on the basis of chemical transformation, elemental analysis, equivalent weight determination and IR, ¹H NMR spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram-negative microorgansms.

Keywords

Synthesis, Biological activity, Triazolo-thiadiazines