Studies on Synthesis of Some New Sydnone Containing Compounds and Their Biological Activities

Chem Sci Trans., 2013, 2(2), pp 589-597

DOI:10.7598/cst2013.424

Research Article

Studies on Synthesis of Some New Sydnone Containing Compounds and Their Biological Activities

Abstract

Some new sydnone derivatives 3-[4-(morpholin-4-yl)phenyl]-4-(secondary substituted amino-4-yl methyl)-sydnone 6(a-j), 3-[4-(morpholin-4-yl) phenyl]-4-(secondary substituted amino-4-yl sulfonyl) sydnone 8(a-j) were synthesized starting from 4-chloroaniline (1). The characterization of the newly synthesized compounds was established by IR, ¹H NMR, ¹³C NMR and Elemental analysis. The final compounds were tested for their antimicrobial activity against several microbes.