Abstract

Three visible spectrophotometric methods have been described for the assay of ceftazidime (CTZ) either in bulk form or dosage forms. Methods A-C are based on the oxidation of CTZ with an excess of oxidant (N-bromosuccinimide (NBS) in methods A and B or chloramine-T (CAT) in method C) in acidic medium. The unreacted oxidant was then estimated colorimetrically by using an oxidisable dye (Celistine blue (CB) in method A or gallocyanine (GC) in method C) or by p-N-methyl aminophenol sulphate (PMAP)- sulphanilamide (SA) reagent in method B. Regression analysis of Beer’s law plots showed good concentration range 2.0-10.0 µg/mL, 4.0-16.0 µg/mL and 1.0-8.0 µg/mL for methods A, B and C respectively and gives reproducible results.

Keywords

Spectrophotometry, NBS, Ceftazidime , Gallocyanine