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  • Chem Sci Trans., 2012, 1(2),  pp 401-409  

    DOI:10.7598/cst2012.175

    Research Article

    Synthesis, Characterization, Anti-Microbial and Anti-Cancer Activity of Novel Heterocyclic System Containing Bridgehead Nitrogen Atom

  • N.SIVASUBRAMANIAN*, M.VIKRAMADITYA REDDY, M.ARAVINDA, R.SRAVANTHI and S.SIRISHA,
  • Department of Pharmaceutical Chemistry, Pulla Reddy Institute of Pharmacy, Annaram(V), Medak-Dt. Pin- 502313, India
  • Abstract

    Condensed quinazolines like thiadiazolo quinazolines and corresponding bioisostere thiadiazolo thienopyrimidines were found to be biologically active molecules. An attempt was made to utilize the concept of bio-isosterism for the synthesis of 3-amino2- mercapto5, 6, 7, 8-tetrahydro-benzo (b)thieno-(2,3-d)-pyrimidine-4-(3H)-ones which was further treated with acetylchloride, urea, carbondisuiphide, chloroacetic acid, benzoin to affords novel fused thiadiazole, thiadiazine compounds. The novel synthesized compounds were characterized by MP, IR, 1H NMR spectra. These synthesized compounds were subjected to anti-microbial studies using few gram-positive, gram-negative and fungal organisms. The standard drug used for anti-microbial activity was ampicillin and ketoconazole respectively and also tested for their anti-cancer activity by MTT assay method. The tested compounds exhibited significant antimicrobial and anti-cancer activity.

    Keywords

    Benzothienopyrimidines, Thiadiazoles, Thiadiazines, Anti-microbial activity, Anti- cancer activity

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